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Sepsis intensifies this vicious cycle, with gut-derived toxins and cytokines (e.g., IL-6 and TNF-) synergizing to precipitate acute renal failure and multiorgan collapse, which is often resistant to conventional dialysis

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Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X, Li C, Shen G, Zou B

When considering oxidative stress and lipid peroxidation, one must consider the regulated form of cell death, ferroptosis, as the accumulation of lipid peroxides is considered a key factor in the onset of ferroptosis (Zhang et al